Bibliographical References for “How to Live 150 years in Health”

The book “How to live 150 years in Health” by Dr. Tsoukalas refers to many scientific and medical researches.

It would have been impossible to include on the pages of the book all the bibliographical references used by the author.

This page will give you some insights on the topics covered in the book and provide the associated extensive bibliography.

Chapter 1

  • Driver, Julia. “The History of Utilitarianism.” Stanford Encyclopedia of Philosophy, Stanford University, 22 Sept. 2014
  • Guggenheim, E. A. Thermodynamics: an Advanced Treatment for Chemists and Physicists. North-Holland, 1993.
  • Rubi, Miguel J. “Does Nature Break the Second Law of Thermodynamics.” Scinetific American, 2008, available at: www.scientificamerican.com/article/how-nature-breaks-the-second-law/.
  • Edelstein, Ludwig. The Hippocratic Oath, Text, Translation and Interpretation by Ludwig Edelstein. Johns Hopkins Press, 1943.

Chapter 2

  • World Health Organization, World Health Organization, www.who.int/.
  • Narasimhan, Ashok, and Menas C. Kafatos. “Wave Particle Duality, the Observer and Retrocausality.”, Melissa Patterson, AIP, May 2017, doi:10.1063/1.4982780.
  • Eccleston, Alex, et al. “Epigenetics.” Nature, vol. 447, no. 7143, 2007, pp. 395–395., doi:10.1038/447395a.
  • Harvard Health Publishing. “Why People Become Overweight.” Harvard Health, June 2009, available at: www.health.harvard.edu/newsweek/Why-people-become-overweight.htm.
  • Rappaport, S. M., and M. T. Smith. “Environment and Disease Risks.” Science, vol. 330, no. 6003, 2010, pp. 460–461., doi:10.1126/science.1192603.
  • Willett, W. C. “Balancing Life-Style and Genomics Research for Disease Prevention.” Science, vol. 296, no. 5568, 2002, pp. 695–698., doi:10.1126/science.1071055.
  • Lipton, Bruce H. The Biology of Belief. Spirit 2000, Inc., 2005.
  • Lipton, Bruce H., and Steve Bhaerman. Spontaneous Evolution: Our Positive Future (and a Way to Get There from Here). Hay House, 2012.
  • Friedland, Gerald. “Discovery of the function of the heart and circulation of blood.” Cardiovascular journal of Africa vol. 20,3 (2009): 160.
  • McRobbie, Donald W., et al. MRI from Picture to Proton. Cambridge University Press, 2017, 3rd edition.
  • Kelly, C. “Functional Correction of Short-Chain Acyl-CoA Dehydrogenase Deficiency in Transgenic Mice: Implications for Gene Therapy of Human Mitochondrial Enzyme Deficiencies.” Human Molecular Genetics, vol. 6, no. 9, 1997, pp. 1451–1455., doi:10.1093/hmg/6.9.1451.
  • Zacchia, Miriam, and Patricia Preisig. “Low urinary citrate: an overview.” Journal of nephrology vol. 23 Suppl 16 (2010): S49-56.
  • Dudley, E., et al. “Targeted Metabolomics and Mass Spectrometry.” Advances in Protein Chemistry and Structural Biology, 2010, pp. 45–83., doi:10.1016/b978-0-12-381264-3.00002-3.
  • Tsoukalas, Dimitris et al. “Metabolic Fingerprint of Chronic Obstructive Lung Diseases: A New Diagnostic Perspective.” Metabolites vol. 9,12 290. 26 Nov. 2019, doi:10.3390/metabo9120290
  • Raines, Jeremy K. “Electromagnetic Field Interactions with the Human Body: Observed Effects and Theories.” NASA, NASA, 9 Apr. 1981, ntrs.nasa.gov/search.jsp?R=19810017132.
  • Biémont, C. “From genotype to phenotype. What do epigenetics and epigenomics tell us?.” Heredity vol. 105,1 (2010): 1-3. doi:10.1038/hdy.2010.66

Chapter 3

  • “POP101: A Primer on the Future of Planet Earth.” Overpopulation Is a Myth, 29 Aug. 2017, www.overpopulationisamyth.com/.
  • Vaupel, James W. “Biodemography of Human Ageing.” Nature News, Nature Publishing Group, 24 Mar. 2010, www.nature.com/articles/nature08984#citeas.
  • “Measles Log .” Http://Childhealthsafety.com/, 2009, childhealthsafety.com/.
  • Aunan, J R et al. “Molecular and biological hallmarks of ageing.” The British journal of surgery vol. 103,2 (2016): e29-46. doi:10.1002/bjs.10053
  • Rosling, Hans. “The Joy of Stats, Hans Rosling’s 200 Countries, 200 Years, 4 Minutes.” BBC Four, BBC, 30 Nov. 2010, www.bbc.co.uk/programmes/p00cgkfk.
  • Bunker, John P. “The Role of Medical Care in Contributing to Health Improvements within Societies.” International Journal of Epidemiology, vol. 30, no. 6, 2001, pp. 1260–1263., doi:10.1093/ije/30.6.1260.
  • Colditz, Graham A. “Efficacy of BCG Vaccine in the Prevention of Tuberculosis.” Jama, vol. 271, no. 9, 1994, p. 698., doi:10.1001/jama.1994.03510330076038.
  • Partridge, Linda, et al. “The New Science of Ageing.” Philosophical Transactions of the Royal Society B: Biological Sciences, vol. 366, no. 1561, 2011, pp. 6–8., doi:10.1098/rstb.2010.0298.
  • Grady, Deborah. “Less Is More.” Archives of Internal Medicine, vol. 170, no. 9, 2010, p. 749., doi:10.1001/archinternmed.2010.90.
  • Magalhães, João Pedro De, et al. “An Analysis of the Relationship Between Metabolism, Developmental Schedules, and Longevity Using Phylogenetic Independent Contrasts.” The Journals of Gerontology: Series A, vol. 62, no. 2, 2007, pp. 149–160., doi:10.1093/gerona/62.2.149.
  • Amir, Saira, et al. “Sperm Telomere Length: Diagnostic and Prognostic Biomarker in Male Infertility (Review).” World Academy of Sciences Journal, 2020, doi:10.3892/wasj.2020.31.
  • Tsoukalas, Dimitris, et al. “Discovery of Potent Telomerase Activators: Unfolding New Therapeutic and Anti-Aging Perspectives.” Molecular Medicine Reports, 2019, doi:10.3892/mmr.2019.10614.
  • Tsoukalas, Dimitris, et al. “Association of Nutraceutical Supplements with Longer Telomere Length.” International Journal of Molecular Medicine, 2019, doi:10.3892/ijmm.2019.4191.
  • Vasilopoulos, Eleni et al. “The association of female and male infertility with telomere length (Review).” International journal of molecular medicine vol. 44,2 (2019): 375-389. doi:10.3892/ijmm.2019.4225
  • Tsatsakis, Aristidis, et al. “Developing BIOTEL: A Semi-Automated Spreadsheet for Estimating Telomere Length and Biological Age.” Frontiers in Genetics, vol. 10, 2019, doi:10.3389/fgene.2019.00084.
  • Vakonaki, E.k., et al. “Decreased Telomeres Length in Patients with Glioblastoma Multiform.” Toxicology Letters, vol. 295, 2018, doi:10.1016/j.toxlet.2018.06.582.
  • Ozcagli, Eren, et al. “Stanozolol Administration Combined with Exercise Leads to Decreased Telomerase Activity Possibly Associated with Liver Aging.” International Journal of Molecular Medicine, 2018, doi:10.3892/ijmm.2018.3644.
  • Fragkiadaki, Persefoni et al. “Telomerase activity in pregnancy complications (Review).” Molecular medicine reports vol. 14,1 (2016): 16-21. doi:10.3892/mmr.2016.5231

Chapter 4

  • Ness, A. “Diet, Nutrition and the Prevention of Chronic Diseases. WHO Technical Report Series 916. Report of a Joint WHO/FSA Expert Consultation.” International Journal of Epidemiology, vol. 33, no. 4, 2004, pp. 914–915., doi:10.1093/ije/dyh209.
  • Tulchinsky, Theodore H. “Micronutrient Deficiency Conditions: Global Health Issues.” Public Health Reviews, vol. 32, no. 1, 2010, pp. 243–255., doi:10.1007/bf03391600.
  • Ames, B. N. “Low Micronutrient Intake May Accelerate the Degenerative Diseases of Aging through Allocation of Scarce Micronutrients by Triage.” Proceedings of the National Academy of Sciences, vol. 103, no. 47, 2006, pp. 17589–17594., doi:10.1073/pnas.0608757103.
  • Balch, Phyllis A. Prescription for Dietary Wellness. Penguin Group, 2003.
  • From Rio to Rio+20: Progress and Challenges since the 1992 Earth Summit United Nations Conference on Sustainable Development United Nations Department of Public Information, June 2012
  • Musio, Silvia, et al. “A Key Regulatory Role for Histamine in Experimental Autoimmune Encephalomyelitis: Disease Exacerbation in Histidine Decarboxylase-Deficient Mice.” The Journal of Immunology, vol. 176, no. 1, 2005, pp. 17–26., doi:10.4049/jimmunol.176.1.17.
  • Anderson, Sandra D. “How Does Exercise Cause Asthma Attacks?” Current Opinion in Allergy and Clinical Immunology, vol. 6, no. 1, 2006, pp. 37–42., doi:10.1097/01.all.0000199797.02423.78.
  • Schomburg, Lutz. “Selenium, Selenoproteins and the Thyroid Gland: Interactions in Health and Disease.” Nature Reviews Endocrinology, vol. 8, no. 3, 2011, pp. 160–171., doi:10.1038/nrendo.2011.174.
  • Grenham, Sue, et al. “Brain Gut Microbe Communication in Health and Disease.” Frontiers in Physiology, vol. 2, 2011, doi:10.3389/fphys.2011.00094.
  • “Autoimmune Info – American Autoimmune Related Diseases Association.” AARDA, 2018, www.aarda.org/.
  • Freedman, D. M., et al. “Vitamin D and Cancer Mortality.” Cancer Epidemiology Biomarkers & Prevention, vol. 18, no. 1, 2009, pp. 359–359., doi:10.1158/1055-9965.epi-08-0633.
  • Atoum, Manar, and Foad Alzoughool. “Vitamin D and Breast Cancer: Latest Evidence and Future Steps.” Breast Cancer: Basic and Clinical Research, vol. 11, 2017, p. 117822341774981., doi:10.1177/1178223417749816.
  • Gorham, Edward D., et al. “Vitamin D and Prevention of Colorectal Cancer.” The Journal of Steroid Biochemistry and Molecular Biology, vol. 97, no. 1-2, 2005, pp. 179–194., doi:10.1016/j.jsbmb.2005.06.018.
  • Volkov, I, et al. “Successful Treatment of Recurrent Aphthous Stomatitis of Any Origin with Vitamin B12 (Irrespective of Its Blood Level).” The Internet Journal of Family Practice, vol. 5, no. 1, 2007, doi:10.5580/2477.
  • “Vitamin B12 Link to Alzheimer’s Backed by Study.” BBC News, BBC, 19 Oct. 2010, www.bbc.com/news/health-11569602.
  • Enns, Cecilia & Goldman, J.D. & Cook, A.. (1997). Trends in food and nutrient intakes by adults: NFCS 1977-78, CSFII 1989-91, and CSFII 1994-95. Fam Econ Nutr Rev. 10.
  • Bernatsky, Sasha et al. “Associations between ambient fine particulate levels and disease activity in patients with systemic lupus erythematosus (SLE).” Environmental health perspectives vol. 119,1 (2011): 45-9. doi:10.1289/ehp.1002123
  • Elias, Kevin M., et al. “Retinoic Acid Inhibits Th17 Polarization and Enhances FoxP3 Expression through a Stat-3/Stat-5 Independent Signaling Pathway.” Blood, vol. 111, no. 3, 2008, pp. 1013–1020., doi:10.1182/blood-2007-06-096438.
  • Ebers, G. C., et al. “Vitamin D Intake and Incidence of Multiple Sclerosis.” Neurology, vol. 63, no. 5, 2004, pp. 939–939., doi:10.1212/wnl.63.5.939.

Chapter 5

  • Tanaka, K et al. “Isovaleric acidemia: a new genetic defect of leucine metabolism.” Proceedings of the National Academy of Sciences of the United States of America vol. 56,1 (1966): 236-42. doi:10.1073/pnas.56.1.236
  • Radzicka, A, and R Wolfenden. “A Proficient Enzyme.” Science, vol. 267, no. 5194, 1995, pp. 90–93., doi:10.1126/science.7809611.
  • Tsoukalas, Dimitris, et al. “Targeted Metabolomic Analysis of Serum Fatty Acids for the Prediction of Autoimmune Diseases.” Frontiers in Molecular Biosciences, vol. 6, 2019, doi:10.3389/fmolb.2019.00120.
  • Vockley, Jerry, and Regina Ensenauer. “Isovaleric Acidemia: New Aspects of Genetic and Phenotypic Heterogeneity.” American Journal of Medical Genetics Part C: Seminars in Medical Genetics, vol. 142C, no. 2, 2006, pp. 95–103., doi:10.1002/ajmg.c.30089.
  • Horning, E C, and M G Horning. “Metabolic Profiles: Gas-Phase Methods for Analysis of Metabolites.” Clinical Chemistry, vol. 17, no. 8, 1971, pp. 802–809., doi:10.1093/clinchem/17.8.802.
  • Tsoukalas, Dimitris et al. Metabolic Fingerprint of Chronic Obstructive Lung Diseases: A New Diagnostic Perspective. Metabolites 2019, 9(12), 290;  26 November 2019 doi: 10.3390/metabo9120290
  • “The Fingerprints of Diabetes…and Other Diseases.” Harvard Magazine, 3 Mar. 2014, available at: harvardmagazine.com/2011/05/the-fingerprints-of-diabetes-and-other-diseases.
  • Pauling, L., et al. “Quantitative Analysis of Urine Vapor and Breath by Gas-Liquid Partition Chromatography.” Proceedings of the National Academy of Sciences, vol. 68, no. 10, 1971, pp. 2374–2376., doi:10.1073/pnas.68.10.2374.
  • Jansson, Janet, et al. “Metabolomics Reveals Metabolic Biomarkers of Crohn’s Disease.” PLoS ONE, vol. 4, no. 7, 2009, doi:10.1371/journal.pone.0006386.
  • Seeger, Karsten. “Metabolic Changes in Autoimmune Diseases.” Current Drug Discovery Technologies, vol. 6, no. 4, 2009, pp. 256–261., doi:10.2174/157016309789869074.
  • Spratlin, J. L., et al. “Clinical Applications of Metabolomics in Oncology: A Review.” Clinical Cancer Research, vol. 15, no. 2, 2009, pp. 431–440., doi:10.1158/1078-0432.ccr-08-1059.
  • Lewis, Gregory D., and Robert E. Gerszten. “Application of Metabolomics to Cardiovascular Biomarker and Pathway Discovery.” Clinical Proteomics, 2008, pp. 279–293., doi:10.1002/9783527622153.ch19.\
  • Kim, Ji Young, et al. “Metabolic Profiling of Plasma in Overweight/Obese and Lean Men Using Ultra Performance Liquid Chromatography and Q-TOF Mass Spectrometry (UPLC−Q-TOF MS).” Journal of Proteome Research, vol. 9, no. 9, 2010, pp. 4368–4375., doi:10.1021/pr100101p.

Chapter 6

  • Tanaka, K., et al. “Isovaleric Acidemia: a New Genetic Defect of Leucine Metabolism.” Proceedings of the National Academy of Sciences, vol. 56, no. 1, 1966, pp. 236–242., doi:10.1073/pnas.56.1.236.
  • Radzicka, A, and R Wolfenden. “A Proficient Enzyme.” Science, vol. 267, no. 5194, 1995, pp. 90–93., doi:10.1126/science.7809611.
  • Vockley, Jerry, and Regina Ensenauer. “Isovaleric Acidemia: New Aspects of Genetic and Phenotypic Heterogeneity.” American Journal of Medical Genetics Part C: Seminars in Medical Genetics, vol. 142C, no. 2, 2006, pp. 95–103., doi:10.1002/ajmg.c.30089.
  • Horning, E C, and M G Horning. “Metabolic Profiles: Gas-Phase Methods for Analysis of Metabolites.” Clinical Chemistry, vol. 17, no. 8, 1971, pp. 802–809., doi:10.1093/clinchem/17.8.802.
  • “The Fingerprints of Diabetes…and Other Diseases.” Harvard Magazine, 3 Mar. 2014, available at: harvardmagazine.com/2011/05/the-fingerprints-of-diabetes-and-other-diseases.
  • Ford, Earl S, et al. “Healthy Living Is the Best Revenge:Findings From the European Prospective Investigation Into Cancer and Nutrition-Potsdam Study.” Archives of Internal Medicine, vol. 169, no. 15, 2009, p. 1355., doi:10.1001/archinternmed.2009.237.

Chapter 7

  • Pauling, L., et al. “Quantitative Analysis of Urine Vapor and Breath by Gas-Liquid Partition Chromatography.” Proceedings of the National Academy of Sciences, vol. 68, no. 10, 1971, pp. 2374–2376., doi:10.1073/pnas.68.10.2374.
  • Jansson, Janet, et al. “Metabolomics Reveals Metabolic Biomarkers of Crohn’s Disease.” PLoS ONE, vol. 4, no. 7, 2009, doi:10.1371/journal.pone.0006386.
  • Seeger, Karsten. “Metabolic Changes in Autoimmune Diseases.” Current Drug Discovery Technologies, vol. 6, no. 4, 2009, pp. 256–261., doi:10.2174/157016309789869074.
  • Spratlin, J. L., et al. “Clinical Applications of Metabolomics in Oncology: A Review.” Clinical Cancer Research, vol. 15, no. 2, 2009, pp. 431–440., doi:10.1158/1078-0432.ccr-08-1059.
  • Lewis, Gregory D., and Robert E. Gerszten. “Application of Metabolomics to Cardiovascular Biomarker and Pathway Discovery.” Clinical Proteomics, 2008, pp. 279–293., doi:10.1002/9783527622153.ch19.\
  • Kim, Ji Young, et al. “Metabolic Profiling of Plasma in Overweight/Obese and Lean Men Using Ultra Performance Liquid Chromatography and Q-TOF Mass Spectrometry (UPLC−Q-TOF MS).” Journal of Proteome Research, vol. 9, no. 9, 2010, pp. 4368–4375., doi:10.1021/pr100101p.
  • Chakravarti, Aravinda. “Genomics Is Not Enough.” Science Mag, 7 Oct. 2011,available at: science.sciencemag.org/content/334/6052/15.
  • Lord, Richard S., and J. Alexander. Bralley. Laboratory Evaluations for Integrative and Functional Medicine. 2nd ed., Genova Diagnostics, 2008.
  • German, J. B., et al. “Metabolomics and Individual Metabolic Assessment: The Next Great Challenge for Nutrition.” The Journal of Nutrition, vol. 132, no. 9, 2002, pp. 2486–2487., doi:10.1093/jn/132.9.2486.
  • German, J. Bruce, et al. “Metabolomics in Practice: Emerging Knowledge to Guide Future Dietetic Advice toward Individualized Health.” Journal of the American Dietetic Association, vol. 105, no. 9, 2005, pp. 1425–1432., doi:10.1016/j.jada.2005.06.006.
  • Zivkovic, Angela M, and J Bruce German. “Metabolomics for Assessment of Nutritional Status.” Current Opinion in Clinical Nutrition and Metabolic Care, vol. 12, no. 5, 2009, pp. 501–507., doi:10.1097/mco.0b013e32832f1916.
  • Pieczenik, Steve R., and John Neustadt. “Mitochondrial Dysfunction and Molecular Pathways of Disease.” Experimental and Molecular Pathology, vol. 83, no. 1, 2007, pp. 84–92., doi:10.1016/j.yexmp.2006.09.008.
  • Indrio, Flavia, et al. “Regurgitation in Healthy and Non Healthy Infants.” Italian Journal of Pediatrics, 9 Dec. 2009, doi:https://doi.org/10.1186/1824-7288-35-39.
  • Seely, Ellen W. “Editorial Overview.” Current Opinion in Endocrinology, Diabetes and Obesity, vol. 17, no. 3, 2010, p. 187., doi:10.1097/med.0b013e3283394ef4.
  • Bournat, Juan C, and Chester W Brown. “Mitochondrial Dysfunction in Obesity.” Current Opinion in Endocrinology, Diabetes and Obesity, vol. 17, no. 5, 2010, pp. 446–452., doi:10.1097/med.0b013e32833c3026.

Chapter 8

  • Tsoukalas, Dimitris, et al. “Anthropogenic Pressure and Lifestyle Are the Underlying Cause of Pandemic Chronic Diseases.” Journal of Siberian Federal University. Biology, 2019, pp. 233–243., doi:10.17516/1997-1389-0297.
  • Boone, Jeffrey L, and Jeffrey P Anthony. “Evaluating the impact of stress on systemic disease: the MOST protocol in primary care.” The Journal of the American Osteopathic Association vol. 103,5 (2003): 239-46.
  • Selye, H. “Stress and Disease.” Science, vol. 122, no. 3171, 1955, pp. 625–631., doi:10.1126/science.122.3171.625.
  • Slavich, George M. “Life Stress and Health.” Teaching of Psychology, vol. 43, no. 4, 2016, pp. 346–355., doi:10.1177/0098628316662768.

Chapter 9

  • Simopoulos, Artemis P. “The Importance of the Omega-6/Omega-3 Fatty Acid Ratio in Cardiovascular Disease and Other Chronic Diseases.” Experimental Biology and Medicine, vol. 233, no. 6, 2008, pp. 674–688., doi:10.3181/0711-mr-311.
  • Mesnage, Robin, et al. “Gut Microbiome Metagenomics to Understand How Xenobiotics Impact Human Health.” Current Opinion in Toxicology, vol. 11-12, 2018, pp. 51–58., doi:10.1016/j.cotox.2019.02.002.
  • Papamichael, Maria Michelle, et al. “Weight Status and Respiratory Health in Asthmatic Children.” Lung, vol. 197, no. 6, 2019, pp. 777–782., doi:10.1007/s00408-019-00273-w.
  • Papamichael, M. M., et al. “Efficacy of a Mediterranean Diet Supplemented with Fatty Fish in Ameliorating Inflammation in Paediatric Asthma: a Randomised Controlled Trial.” Journal of Human Nutrition and Dietetics, vol. 32, no. 2, 2018, pp. 185–197., doi:10.1111/jhn.12609.
  • Tsoukalas, Dimitris, et al. “Application of Metabolomics Part II: Focus on Fatty Acids and Their Metabolites in Healthy Adults.” International Journal of Molecular Medicine, 2018, doi:10.3892/ijmm.2018.3989.
  • Hubbard, L. Ron. Clear Body, Clear Mind: the Effective Purification Program. Bridge Publications, 1990, 1st edition.
  • Costa, Chiara, et al. “Current Evidence on the Effect of Dietary Polyphenols Intake on Chronic Diseases.” Food and Chemical Toxicology, vol. 110, 2017, pp. 286–299., doi:10.1016/j.fct.2017.10.023.
  • Engin, Ayse Basak, et al. “Do Flavanols-Rich Natural Products Relieve Obesity-Related Insulin Resistance?” Food and Chemical Toxicology, vol. 112, 2018, pp. 157–167, doi:10.1016/j.fct.2017.12.055.
  • Nitulescu, George, et al. “The Akt Pathway in Oncology Therapy and beyond (Review).” International Journal of Oncology, 2018, doi:10.3892/ijo.2018.4597.
  • Zanfirescu, Anca, et al. “A Review of the Alleged Health Hazards of Monosodium Glutamate.” Comprehensive Reviews in Food Science and Food Safety, vol. 18, no. 4, 2019, pp. 1111–1134., doi:10.1111/1541-4337.12448.
  • “Healthy Eating Plate.” The Nutrition Source, 22 Nov. 2019, available at: www.hsph.harvard.edu/nutritionsource/what-should-you-eat/pyramid/.
  • Cox, B. D, and M. J Whichelow. “Frequent Consumption of Red Meat Is Not Risk Factor for Cancer.” Bmj, vol. 315, no. 7114, 1997, pp. 1018–1018., doi:10.1136/bmj.315.7114.1018a.
  • Carroll, K K. “Dietary Fats and Cancer.” The American Journal of Clinical Nutrition, vol. 53, no. 4, 1991, doi:10.1093/ajcn/53.4.1064s.
  • Mie, Axel, et al. “Human Health Implications of Organic Food and Organic Agriculture: a Comprehensive Review.” Environmental Health, vol. 16, no. 1, 2017, doi:10.1186/s12940-017-0315-4.

Chapter 10

Pludowski, Pawel, et al. “Vitamin D Effects on Musculoskeletal Health, Immunity, Autoimmunity, Cardiovascular Disease, Cancer, Fertility, Pregnancy, Dementia and Mortality—A Review of Recent Evidence.” Autoimmunity Reviews, vol. 12, no. 10, 2013, pp. 976–989., doi:10.1016/j.autrev.2013.02.004.

  • Heaney, Robert P. “Assessing Vitamin D Status.” Current Opinion in Clinical Nutrition and Metabolic Care, vol. 14, no. 5, 2011, pp. 440–444., doi:10.1097/mco.0b013e328348ed85.
  • Garland, Cedric F., et al. “Vitamin D for Cancer Prevention: Global Perspective.” Annals of Epidemiology, vol. 19, no. 7, 2009, pp. 468–483., doi:10.1016/j.annepidem.2009.03.021.
  • Atoum, Manar, and Foad Alzoughool. “Vitamin D and Breast Cancer: Latest Evidence and Future Steps.” Breast Cancer: Basic and Clinical Research, vol. 11, 2017, p. 117822341774981., doi:10.1177/1178223417749816.
  • Gorham, Edward D., et al. “Vitamin D and Prevention of Colorectal Cancer.” The Journal of Steroid Biochemistry and Molecular Biology, vol. 97, no. 1-2, 2005, pp. 179–194., doi:10.1016/j.jsbmb.2005.06.018.
  • “Unraveling the Enigma of Vitamin D.” National Academy of Sciences, Oct. 2000, available at: www.nasonline.org/publications/beyond-discovery/vitamin-d.pdf.
  • Pilz, Stefan, et al. “Vitamin D Status and Arterial Hypertension: a Systematic Review.” Nature Reviews Cardiology, vol. 6, no. 10, 2009, pp. 621–630., doi:10.1038/nrcardio.2009.135.
  • Kinney, Dennis K., et al. “Environmental Risk Factors for Autism: Do They Help Cause De Novo Genetic Mutations That Contribute to the Disorder?” Medical Hypotheses, vol. 74, no. 1, 2010, pp. 102–106., doi:10.1016/j.mehy.2009.07.052.
  • Kulie, T., et al. “Vitamin D: An Evidence-Based Review.” The Journal of the American Board of Family Medicine, vol. 22, no. 6, 2009, pp. 698–706., doi:10.3122/jabfm.2009.06.090037.

Chapter 11

  • Sedelmeier, Gottfried, and Joerg Sedelmeier. “Top 200 Drugs by Worldwide Sales 2016.” Chimia vol. 71,10 (2017): 730. doi:10.2533/chimia.2017.730
  • Quigley, Eamonn M.m., and Rodrigo Quera. “Small Intestinal Bacterial Overgrowth: Roles of Antibiotics, Prebiotics, and Probiotics.” Gastroenterology, vol. 130, no. 2, 2006, doi:10.1053/j.gastro.2005.11.046.
  • Ali, Tauseef, et al. “Long-Term Safety Concerns with Proton Pump Inhibitors.” The American Journal of Medicine, vol. 122, no. 10, 2009, pp. 896–903., doi:10.1016/j.amjmed.2009.04.014.
  • Rabin, Roni Caryn. “Combating Acid Reflux May Bring Host of Ills.” The New York Times, The New York Times, 25 June 2012, available at: well.blogs.nytimes.com/2012/06/25/combating-acid-reflux-may-bring-host-of-ills/.
  • “Use of Stomach Drugs Debated.” NHS Choices, NHS, 11 May 2010, available at: www.nhs.uk/news/2010/05may/pages/ppi-stomach-drugs-harm-vs-good.aspx.
  • Piessevaux, H., et al. “Dyspeptic Symptoms in the General Population: a Factor and Cluster Analysis of Symptom Groupings.” Neurogastroenterology & Motility, vol. 21, no. 4, 2009, pp. 378–388., doi:10.1111/j.1365-2982.2009.01262.x.
  • Heading, R C. “Prevalence of upper gastrointestinal symptoms in the general population: a systematic review.” Scandinavian journal of gastroenterology. Supplement vol. 231 (1999): 3-8.
  • Lyte, Mark. “Probiotics Function Mechanistically as Delivery Vehicles for Neuroactive Compounds: Microbial Endocrinology in the Design and Use of Probiotics.” BioEssays, vol. 33, no. 8, 2011, pp. 574–581., doi:10.1002/bies.201100024.
  • Reid, Gregor. “Neuroactive Probiotics.” BioEssays, vol. 33, no. 8, 2011, pp. 562–562., doi:10.1002/bies.201100074.
  • “Kurzweilaccelerating Intelligence.” Kurzweil That Gut Feeling How Stomach Bacteria Impact Brain Chemistry and Behavior Comments, available at: www.kurzweilai.net/that-gut-feeling-how-stomach-bacteria-impact-brain-chemistry-and-behavior.
  • Hong, Young-Shick, et al. “Metabonomic Understanding of Probiotic Effects in Humans With Irritable Bowel Syndrome.” Journal of Clinical Gastroenterology, vol. 45, no. 5, 2011, pp. 415–425., doi:10.1097/mcg.0b013e318207f76c.
  • Jiménez, M. Bixquert. “Treatment of Irritable Bowel Syndrome with Probiotics: An Etiopathogenic Approach at Last?” Revista Española De Enfermedades Digestivas, vol. 101, no. 8, 2009, doi:10.4321/s1130-01082009000800006.
  • Bischoff, Stephan C, et al. “Intestinal Permeability – a New Target for Disease Prevention and Therapy.” BMC Gastroenterology, vol. 14, no. 1, 2014, doi:10.1186/s12876-014-0189-7.
  • Mu, Qinghui, et al. “Leaky Gut As a Danger Signal for Autoimmune Diseases.” Frontiers in Immunology, vol. 8, 2017, doi:10.3389/fimmu.2017.00598.
  • Demeo, Mark T., et al. “Intestinal Permeation and Gastrointestinal Disease.” Journal of Clinical Gastroenterology, vol. 34, no. 4, 2002, pp. 385–396., doi:10.1097/00004836-200204000-00003.
  • Liu, Z et al. “Tight junctions, leaky intestines, and pediatric diseases.” Acta paediatrica (Oslo, Norway : 1992) vol. 94,4 (2005): 386-93. doi:10.1111/j.1651-2227.2005.tb01904.x
  • Fasano, Alessio. “Zonulin and its regulation of intestinal barrier function: the biological door to inflammation, autoimmunity, and cancer.” Physiological reviews vol. 91,1 (2011): 151-75. doi:10.1152/physrev.00003.2008
  • Vine, D F et al. “Effect of dietary fatty acids on the intestinal permeability of marker drug compounds in excised rat jejunum.” The Journal of pharmacy and pharmacology vol. 54,6 (2002): 809-19. doi:10.1211/0022357021779159

Chapter 12

  • Danner, Deborah D., et al. “Positive Emotions in Early Life and Longevity: Findings from the Nun Study.” Journal of Personality and Social Psychology, vol. 80, no. 5, 2001, pp. 804–813., doi:10.1037/0022-3514.80.5.804.
  • Nakazawa, Donna Jackson. The Autoimmune Epidemic. Simon & Schuster, 2009.
  • Papamichael, Maria Michelle, et al. “Urinary Organic Acids as Biomarkers in the Assessment of Pulmonary Function in Children with Asthma.” Nutrition Research, vol. 61, 2019, pp. 31–40., doi:10.1016/j.nutres.2018.10.004.
  • “Cell Damage and Autoimmunity Colloquium Draws Internationally Known Researchers.” AARDA, available at: www.aarda.org/.
  • Yang, Chen-Yen, et al. “The Implication of Vitamin D and Autoimmunity: a Comprehensive Review.” Clinical Reviews in Allergy & Immunology, vol. 45, no. 2, 2013, pp. 217–226., doi:10.1007/s12016-013-8361-3.
  • Elias, Kevin M et al. “Retinoic acid inhibits Th17 polarization and enhances FoxP3 expression through a Stat-3/Stat-5 independent signaling pathway.” Blood vol. 111,3 (2008): 1013-20. doi:10.1182/blood-2007-06-096438
  • Shaikh, Saame Raza, and Michael Edidin. “Polyunsaturated Fatty Acids, Membrane Organization, T Cells, and Antigen Presentation.” The American Journal of Clinical Nutrition, vol. 84, no. 6, 2006, pp. 1277–1289., doi:10.1093/ajcn/84.6.1277.
  • “Human Molecular Genetics: Oxford Academic.” OUP Academic, Oxford University Press, 1 Jan. 1753, academic.oup.com/hmg.

Chapter 13

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  • “IOPscience.” IOPscience, iopscience.iop.org/.
  • Dunham, Will. “Cancer to Pass Heart Disease as No. 1 Killer.” Reuters, Thomson Reuters, 9 Dec. 2008, available at: www.reuters.com/article/us-cancer-world/cancer-to-pass-heart-disease-as-no-1-killer-idUSN0918012220081209.
  • Zimmerman, Michael R. “An Experimental Study of Mummification Pertinent to the Antiquity of Cancer.” Cancer, vol. 40, no. 3, 1977, pp. 1358–1362., doi:10.1002/1097-0142(197709)40:33.0.co;2-j.
  • “Physical Activity and Cancer Fact Sheet.” National Cancer Institute, 10 Feb. 2020, available at: www.cancer.gov/about-cancer/causes-prevention/risk/obesity/physical-activity-fact-sheet.
  • Hsu, Isabel R et al. “Metabolic syndrome, hyperinsulinemia, and cancer.” The American journal of clinical nutrition vol. 86,3 (2007): s867-71. doi:10.1093/ajcn/86.3.867S
  • Macrae, Fiona. “Cancer ‘Is Purely Man-Made’ Say Scientists after Finding Almost No Trace of Disease in Egyptian Mummies.” Daily Mail Online, Associated Newspapers, 15 Oct. 2010, available at: www.dailymail.co.uk/sciencetech/article-1320507/Cancer-purely-man-say-scientists-finding-trace-disease-Egyptian-mummies.html.
  • David, A. Rosalie, and Michael R. Zimmerman. “Cancer: an Old Disease, a New Disease or Something in between?” Nature Reviews Cancer, vol. 10, no. 10, 2010, pp. 728–733., doi:10.1038/nrc2914.
  • Gorham, Edward D et al. “Optimal vitamin D status for colorectal cancer prevention: a quantitative meta analysis.” American journal of preventive medicine vol. 32,3 (2007): 210-6. doi:10.1016/j.amepre.2006.11.004
  • Garland, Cedric F et al. “Vitamin D and prevention of breast cancer: pooled analysis.” The Journal of steroid biochemistry and molecular biology vol. 103,3-5 (2007): 708-11. doi:10.1016/j.jsbmb.2006.12.007
  • Devaraj, S et al. “Low vitamin D levels in Northern American adults with the metabolic syndrome.” Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme vol. 43,1 (2011): 72-4. doi:10.1055/s-0030-1268485
  • Laino, Charlene. “Multivitamins May Cut Breast Cancer Risk.” WebMD, WebMD, 19 Apr. 2010, available at: www.webmd.com/breast-cancer/news/20100419/multivitamins-may-cut-breast-cancer-risk.
  • The American Cancer Society and Editorial Content Team. “Family Cancer Syndromes.” American Cancer Society, 2018, available at: www.cancer.org/cancer/cancer-causes/genetics/family-cancer-syndromes.html.
  • Esteller, Manel. “Epigenetics in Cancer.” New England Journal of Medicine, vol. 358, no. 11, 2008, pp. 1148–1159., doi:10.1056/nejmra072067.
  • Roukos, Dimitrios H. “Genome-wide association studies: how predictable is a person’s cancer risk?.” Expert review of anticancer therapy vol. 9,4 (2009): 389-92. doi:10.1586/era.09.12
  • Greenhalgh, Trisha, et al. “Less Research Is Needed.” Speaking of Medicine, 18 May 2020, available at: blogs.plos.org/speakingofmedicine/2012/06/25/less-research-is-needed/.
  • Barrett, Mike, et al. “Compiled Proof That Natural Healing Is Embedded in Natural Foods.” Natural Society, 17 June 2015, available at: naturalsociety.com/compiled-proof-natural-healing-foods-key-optimal-health/.
  • Padayatty, S J, and M Levine. “Vitamin C: the known and the unknown and Goldilocks.” Oral diseases vol. 22,6 (2016): 463-93. doi:10.1111/odi.12446
  • Levine, Mark et al. “Vitamin C: a concentration-function approach yields pharmacology and therapeutic discoveries.” Advances in nutrition (Bethesda, Md.) vol. 2,2 (2011): 78-88. doi:10.3945/an.110.000109
  • Chen, Qi et al. “Pharmacologic doses of ascorbate act as a prooxidant and decrease growth of aggressive tumor xenografts in mice.” Proceedings of the National Academy of Sciences of the United States of America vol. 105,32 (2008): 11105-9. doi:10.1073/pnas.0804226105
  • Padayatty, Sebastian J et al. “Intravenously administered vitamin C as cancer therapy: three cases.” CMAJ : Canadian Medical Association journal = journal de l’Association medicale canadienne vol. 174,7 (2006): 937-42. doi:10.1503/cmaj.050346
  • Roomi, M Waheed, et al. “Modulation of N-Methyl-N-Nitrosourea Induced Mammary Tumors in Sprague–Dawley Rats by Combination of Lysine, Proline, Arginine, Ascorbic Acid and Green Tea Extract.” Breast Cancer Research, vol. 7, no. 3, 2005, doi:10.1186/bcr989.
  • Dringen, Ralf. “Metabolism and Functions of Glutathione in Brain.” Progress in Neurobiology, vol. 62, no. 6, 2000, pp. 649–671., doi:10.1016/s0301-0082(99)00060-x.
  • Block, Keith I et al. “Impact of antioxidant supplementation on chemotherapeutic toxicity: a systematic review of the evidence from randomized controlled trials.” International journal of cancer vol. 123,6 (2008): 1227-39. doi:10.1002/ijc.23754
  • Block, Keith I., et al. “Impact of Antioxidant Supplementation on Chemotherapeutic Efficacy: A Systematic Review of the Evidence from Randomized Controlled Trials.” Cancer Treatment Reviews, vol. 33, no. 5, 2007, pp. 407–418., doi:10.1016/j.ctrv.2007.01.005.
  • Riordan, Hugh D et al. “Intravenous ascorbic acid: protocol for its application and use.” Puerto Rico health sciences journal vol. 22,3 (2003): 287-90.
  • Bowie, A G, and L A O’Neill. “Vitamin C inhibits NF-kappa B activation by TNF via the activation of p38 mitogen-activated protein kinase.” Journal of immunology (Baltimore, Md. : 1950) vol. 165,12 (2000): 7180-8. doi:10.4049/jimmunol.165.12.7180
  • Ahsan, H et al. “Pro-oxidant, anti-oxidant and cleavage activities on DNA of curcumin and its derivatives demethoxycurcumin and bisdemethoxycurcumin.” Chemico-biological interactions vol. 121,2 (1999): 161-75. doi:10.1016/s0009-2797(99)00096-4
  • Arbiser, J L et al. “Curcumin is an in vivo inhibitor of angiogenesis.” Molecular medicine (Cambridge, Mass.) vol. 4,6 (1998): 376-83.
  • Jee, S H et al. “Curcumin induces a p53-dependent apoptosis in human basal cell carcinoma cells.” The Journal of investigative dermatology vol. 111,4 (1998): 656-61. doi:10.1046/j.1523-1747.1998.00352.x
  • Lin, J K, and S Y Lin-Shiau. “Mechanisms of cancer chemoprevention by curcumin.” Proceedings of the National Science Council, Republic of China. Part B, Life sciences vol. 25,2 (2001): 59-66.
  • Plummer, S M et al. “Inhibition of cyclo-oxygenase 2 expression in colon cells by the chemopreventive agent curcumin involves inhibition of NF-kappaB activation via the NIK/IKK signalling complex.” Oncogene vol. 18,44 (1999): 6013-20. doi:10.1038/sj.onc.1202980
  • Ruby, A J et al. “Anti-tumour and antioxidant activity of natural curcuminoids.” Cancer letters vol. 94,1 (1995): 79-83. doi:10.1016/0304-3835(95)03827-j
  • Shoba, G et al. “Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers.” Planta medica vol. 64,4 (1998): 353-6. doi:10.1055/s-2006-957450
  • Hosoe, Kazunori et al. “Study on safety and bioavailability of ubiquinol (Kaneka QH) after single and 4-week multiple oral administration to healthy volunteers.” Regulatory toxicology and pharmacology : RTP vol. 47,1 (2007): 19-28. doi:10.1016/j.yrtph.2006.07.001
  • Schulz, Christiane et al. “Comparison of the relative bioavailability of different coenzyme Q10 formulations with a novel solubilizate (Solu Q10).” International journal of food sciences and nutrition vol. 57,7-8 (2006): 546-55. doi:10.1080/09637480601058320 )
  • “History of Enzyme Therapy.” Dr. Nicholas Gonzalez, available at: www.dr-gonzalez.com/history_of_treatment.htm.

Chapter 14

  • Ravnskov, Uffe, et al. “Lack of an Association or an Inverse Association between Low-Density-Lipoprotein Cholesterol and Mortality in the Elderly: a Systematic Review.” BMJ Open, vol. 6, no. 6, 2016, doi:10.1136/bmjopen-2015-010401.
  • “Classics in arteriosclerosis research: On experimental cholesterin steatosis and its significance in the origin of some pathological processes by N. Anitschkow and S. Chalatow, translated by Mary Z. Pelias, 1913.” Arteriosclerosis (Dallas, Tex.) vol. 3,2 (1983): 178-82.
  • Curtis, Ernest N. The Cholesterol Delusion. Dog Ear Pub., 2010.
  • Golomb, Beatrice A, and Marcella A Evans. “Statin adverse effects : a review of the literature and evidence for a mitochondrial mechanism.” American journal of cardiovascular drugs : drugs, devices, and other interventions vol. 8,6 (2008): 373-418. doi:10.2165/0129784-200808060-00004
  • Kannel, William B. “Cholesterol in the Prediction of Atherosclerotic Disease.” Annals of Internal Medicine, vol. 90, no. 1, 1979, p. 85., doi:10.7326/0003-4819-90-1-85.
  • Anderson, Keaven M. “Cholesterol and Mortality.” Jama, vol. 257, no. 16, 1987, p. 2176., doi:10.1001/jama.1987.03390160062027.
  • Ridker, Paul M. “Clinical Application of C-Reactive Protein for Cardiovascular Disease Detection and Prevention.” Circulation, vol. 107, no. 3, 2003, pp. 363–369., doi:10.1161/01.cir.0000053730.47739.3c.
  • Sever, Peter S et al. “Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations, in the Anglo-Scandinavian Cardiac Outcomes Trial–Lipid Lowering Arm (ASCOT-LLA): a multicentre randomised controlled trial.” Lancet (London, England) vol. 361,9364 (2003): 1149-58. doi:10.1016/S0140-6736(03)12948-0
  • Taylor, Fiona, et al. “Statins for the Primary Prevention of Cardiovascular Disease.” Cochrane Database of Systematic Reviews, 2013, doi:10.1002/14651858.cd004816.pub5.
  • Crea, Filippo, and David A Morrow. “C-Reactive Protein in Cardiovascular Disease.” UpToDate, 2019.
  • Hainer, Ray. “The Cholesterol-Inflammation Connection.” CNN, Cable News Network, 2009, available at: edition.cnn.com/2008/HEALTH/conditions/10/16/healthmag.cholesterol.inflammation/index.html#:~:text=Studies%20show%20that%20a%20substance,attack%20and%20other%20cardiovascular%20events.
  • Journal, The Wall Street. “Chronic Inflammation: The New Science behind America’s Deadliest Diseases.” Fox News, FOX News Network, 13 Nov. 2014, available at: www.foxnews.com/health/2012/07/17/chronic-inflammation-new-science-behind-america-deadliest-diseases/.
  • Anderson, Jeffrey L, et al. “Effect of Folic Acid Fortification of Food on Homocysteine-Related Mortality.” The American Journal of Medicine, vol. 116, no. 3, 2004, pp. 158–164., doi:10.1016/j.amjmed.2003.10.024.
  • Robinson, K et al. “Hyperhomocysteinemia and low pyridoxal phosphate. Common and independent reversible risk factors for coronary artery disease.” Circulation vol. 92,10 (1995): 2825-30. doi:10.1161/01.cir.92.10.2825
  • Maron, Bradley A., and Joseph Loscalzo. “The Treatment of Hyperhomocysteinemia.” Annual Review of Medicine, vol. 60, no. 1, 2009, pp. 39–54., doi:10.1146/annurev.med.60.041807.123308.
  • “History of the Framingham Heart Study.” Framingham Heart Study, available at: framinghamheartstudy.org/fhs-about/history/.
  • Harvard Health Publishing. “Cholesterol.” Harvard Health, www.health.harvard.edu/topics/cholesterol.
  • Hayward, Rodney A., et al. “Narrative Review: Lack of Evidence for Recommended Low-Density Lipoprotein Treatment Targets: A Solvable Problem.” Annals of Internal Medicine, vol. 145, no. 7, 2006, p. 520., doi:10.7326/0003-4819-145-7-200610030-00010.
  • Al-Mallah, Mouaz H et al. “Low admission LDL-cholesterol is associated with increased 3-year all-cause mortality in patients with non ST segment elevation myocardial infarction.” Cardiology journal vol. 16,3 (2009): 227-33.
  • Sherwood, Edward R, and Tracy Toliver-Kinsky. “Mechanisms of the Inflammatory Response.” Best Practice & Research Clinical Anaesthesiology, vol. 18, no. 3, 2004, pp. 385–405., doi:10.1016/j.bpa.2003.12.002.
  • Aguirre, Rene, and James M May. “Inflammation in the vascular bed: importance of vitamin C.” Pharmacology & therapeutics vol. 119,1 (2008): 96-103. doi:10.1016/j.pharmthera.2008.05.002
  • Rath, Matthias, and Linus Pauling. “A Unified Theory of Human Cardiovascular Disease Leading the Way to the Abolition of This Disease as a Cause for Human Mortality.” Journal of Orthomolecular Medicine, vol. 7, no. 1, 1992.
  • Lynch, S M et al. “Ascorbic acid and atherosclerotic cardiovascular disease.” Sub-cellular biochemistry vol. 25 (1996): 331-67. doi:10.1007/978-1-4613-0325-1_17
  • Kim, Hyo Jung et al. “Ascorbic acid synthesis due to L-gulono-1,4-lactone oxidase expression enhances NO production in endothelial cells.” Biochemical and biophysical research communications vol. 345,4 (2006): 1657-62. doi:10.1016/j.bbrc.2006.05.090
  • Román-Viñas, Blanca et al. “Overview of methods used to evaluate the adequacy of nutrient intakes for individuals and populations.” The British journal of nutrition vol. 101 Suppl 2 (2009): S6-11. doi:10.1017/S0007114509990535
  • “Low LDL Cholesterol Is Related to Cancer Risk.” ScienceDaily, ScienceDaily, 26 Mar. 2012, available at: www.sciencedaily.com/releases/2012/03/120326113713.htm.
  • Alsheikh-Ali, Alawi A et al. “Effect of the magnitude of lipid lowering on risk of elevated liver enzymes, rhabdomyolysis, and cancer: insights from large randomized statin trials.” Journal of the American College of Cardiology vol. 50,5 (2007): 409-18. doi:10.1016/j.jacc.2007.02.073
  • Geleijnse, Johanna M et al. “Dietary intake of menaquinone is associated with a reduced risk of coronary heart disease: the Rotterdam Study.” The Journal of nutrition vol. 134,11 (2004): 3100-5. doi:10.1093/jn/134.11.3100

Chapter 15

  • Rosedale, Ron, and Carol Colman. The Rosedale Diet. 1st ed., William Morrow, 2004.
  • “Insulin Resistance & Prediabetes.” National Institute of Diabetes and Digestive and Kidney Diseases, U.S. Department of Health and Human Services, 1 May 2018, available at: www.niddk.nih.gov/health-information/diabetes/overview/what-is-diabetes/prediabetes-insulin-resistance.
  • Olatunbosun, Samuel T. “Insulin Resistance.” Edited by George T Griffing, Practice Essentials, Pathophysiology, Etiology, 30 Mar. 2020, available at: emedicine.medscape.com/article/122501-overview.
  • Reaven, G M. “Insulin resistance, the insulin resistance syndrome, and cardiovascular disease.” Panminerva medica vol. 47,4 (2005): 201-10.
  • Basciano, Heather, et al. “Fructose, Insulin Resistance, and Metabolic Dyslipidemia.” Nutrition & Metabolism, vol. 2, no. 1, 2005, p. 5., doi:10.1186/1743-7075-2-5.
  • Shapiro, Alexandra et al. “Prevention and reversal of diet-induced leptin resistance with a sugar-free diet despite high fat content.” The British journal of nutrition vol. 106,3 (2011): 390-7. doi:10.1017/S000711451100033X
  • Shapiro, Alexandra et al. “Fructose-induced leptin resistance exacerbates weight gain in response to subsequent high-fat feeding.” American journal of physiology. Regulatory, integrative and comparative physiology vol. 295,5 (2008): R1370-5. doi:10.1152/ajpregu.00195.2008
  • Scarpace, Philip J, and Yi Zhang. “Leptin resistance: a prediposing factor for diet-induced obesity.” American journal of physiology. Regulatory, integrative and comparative physiology vol. 296,3 (2009): R493-500. doi:10.1152/ajpregu.90669.2008
  • Hill, Jennifer W et al. “Direct insulin and leptin action on pro-opiomelanocortin neurons is required for normal glucose homeostasis and fertility.” Cell metabolism vol. 11,4 (2010): 286-97. doi:10.1016/j.cmet.2010.03.002
  • Choi, Hyung Jin, et al. “Vitamin K2 Supplementation Improves Insulin Sensitivity via Osteocalcin Metabolism: A Placebo-Controlled Trial.” Diabetes Care, vol. 34, no. 9, 2011, doi:10.2337/dc11-0551.
  • Beulens, Joline W J et al. “Dietary phylloquinone and menaquinones intakes and risk of type 2 diabetes.” Diabetes care vol. 33,8 (2010): 1699-705. doi:10.2337/dc09-2302
  • Khan, Alam et al. “Cinnamon improves glucose and lipids of people with type 2 diabetes.” Diabetes care vol. 26,12 (2003): 3215-8. doi:10.2337/diacare.26.12.3215
  • Akilen, R et al. “Glycated haemoglobin and blood pressure-lowering effect of cinnamon in multi-ethnic Type 2 diabetic patients in the UK: a randomized, placebo-controlled, double-blind clinical trial.” Diabetic medicine : a journal of the British Diabetic Association vol. 27,10 (2010): 1159-67. doi:10.1111/j.1464-5491.2010.03079.x
  • Sheriff, Natasja. “Selenium Linked to Lower Diabetes Risk.” Reuters, Thomson Reuters, 8 June 2012, available at: www.reuters.com/article/2012/06/08/us-selenium-diabetes-risk-idUSBRE85718U20120608.

Chapter 16

  • Mosley, Dr Michael. “The 5:2 Diet: Can It Help You Lose Weight and Live Longer?” The Telegraph, Telegraph Media Group, 16 Aug. 2012, available at: www.telegraph.co.uk/lifestyle/9480451/The-52-diet-can-it-help-you-lose-weight-and-live-longer.html#.
  • Anderson, Rozalyn M et al. “Caloric restriction and aging: studies in mice and monkeys.” Toxicologic pathology vol. 37,1 (2009): 47-51. doi:10.1177/0192623308329476
  • Lane, M A et al. “Caloric restriction in primates.” Annals of the New York Academy of Sciences vol. 928 (2001): 287-95. doi:10.1111/j.1749-6632.2001.tb05658.x
  • Ribarič, Samo. “Diet and aging.” Oxidative medicine and cellular longevity vol. 2012 (2012): 741468. doi:10.1155/2012/741468
  • Turner, Christopher. “The Calorie Restriction Dieters.” The Telegraph, Telegraph Media Group, 25 July 2010, available at: www.telegraph.co.uk/news/health/7898775/The-Calorie-Restriction-dieters.html.
  • Varady, Krista A, and Marc K Hellerstein. “Alternate-day fasting and chronic disease prevention: a review of human and animal trials.” The American journal of clinical nutrition vol. 86,1 (2007): 7-13. doi:10.1093/ajcn/86.1.7
  • Bhutani, Surabhi et al. “Improvements in coronary heart disease risk indicators by alternate-day fasting involve adipose tissue modulations.” Obesity (Silver Spring, Md.) vol. 18,11 (2010): 2152-9. doi:10.1038/oby.2010.54
  • Clemmons, David R. “The Relative Roles of Growth Hormone and IGF-1 in Controlling Insulin Sensitivity.” Journal of Clinical Investigation, vol. 113, no. 1, 2004, pp. 25–27., doi:10.1172/jci20660.
  • Zhou, Y et al. “A mammalian model for Laron syndrome produced by targeted disruption of the mouse growth hormone receptor/binding protein gene (the Laron mouse).” Proceedings of the National Academy of Sciences of the United States of America vol. 94,24 (1997): 13215-20. doi:10.1073/pnas.94.24.13215
  • Guevara-Aguirre, Jaime et al. “Growth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer, and diabetes in humans.” Science translational medicine vol. 3,70 (2011): 70ra13. doi:10.1126/scitranslmed.3001845
  • Wade, Nicholas. “Ecuadorean Villagers May Hold Secret to Longevity.” The New York Times, The New York Times, 16 Feb. 2011, available at: www.nytimes.com/2011/02/17/science/17longevity.html.
  • Bai, Nina. “Defective Growth Gene in Rare Dwarfism Disorder Stunts Cancer and Diabetes.” Scientific American, Scientific American, 17 Feb. 2011, available at: www.scientificamerican.com/article/defective-growth-gene-in-dwarfism/.
  • Rosedale, Ron. “Insulin Resistance: The Real Culprit.”
  • Lee, Changhan et al. “Fasting cycles retard growth of tumors and sensitize a range of cancer cell types to chemotherapy.” Science translational medicine vol. 4,124 (2012): 124ra27. doi:10.1126/scitranslmed.3003293
  • Lee, C, and V D Longo. “Fasting vs dietary restriction in cellular protection and cancer treatment: from model organisms to patients.” Oncogene vol. 30,30 (2011): 3305-16. doi:10.1038/onc.2011.91
  • Park, Alice. “Dwarfism May Hold Key to Fighting Cancer and Diabetes, and Living a Long Life.” TIME, 17 Feb. 2011, available at: healthland.time.com/2011/02/17/dwarfism-may-hold-key-to-fighting-cancer-and-diabetes-and-living-a-long-life/.
  • “World Hunger, Poverty Facts, Statistics 2018.” World Hunger News, 29 Nov. 2018, available at: www.worldhunger.org/world-hunger-and-poverty-facts-and-statistics/.
  • Weston Price Nutrition and Physical Degeneration 1938
  • Williams Roger Biochemical Individuality 1998

Chapter 17

  • Leitch, I. (1942) The evolution of dietary standards. Nutr. Abs. Rev. 11:509-521
  • Murphy, Suzanne P, et al. “History of Nutrition: The Long Road Leading to the Dietary Reference Intakes for the United States and Canada.” Advances in Nutrition, vol. 7, no. 1, 2016, pp. 157–168., doi:10.3945/an.115.010322.
  • Heaney, Robert P. “Vitamin D: Criteria for Safety and Efficacy.” Nutrition Reviews, vol. 66, 2008, doi:10.1111/j.1753-4887.2008.00102.x.
  • News Service, Orthomolecular Medicine. “No Deaths From Vitamins or Minerals.” No Deaths From Vitamins or Minerals, 14 Oct. 2009, available at: www.orthomolecular.org/resources/omns/v05n04.shtml.
  • Lazarou, Jason, et al. “Incidence of Adverse Drug Reactions in Hospitalized Patients: A Meta-Analysis of Prospective Studies.” Survey of Anesthesiology, vol. 43, no. 1, 1999, pp. 53–54., doi:10.1097/00132586-199902000-00059.

Chapter 18

  • Nguyen, D.t., et al. “The Pathophysiologic Basis for Wound Healing and Cutaneous Regeneration.” Biomaterials for Treating Skin Loss, 2009, pp. 25–57., doi:10.1533/9781845695545.1.25.
  • Nguen, D. T., et al. “The Pathophysiologic Basis for Wound Healing and Cutaneous Regeneration.” Biomaterials for Treating Skin Loss, by Dennis Orgill and D. P. Orgill, Woodhead Publishing, 2009, pp. 25–53.
  • Seematter G, Dirlewanger M, Rey V, Schneiter P, Tappy L. Metabolic effects of mental stress during over- and underfeeding in healthy women. Obes Res. 2002;10(1):49‐55. doi:10.1038/oby.2002.7
  • Selye, Hans. The Stress of Life. McGraw-Hill, 1984.
  • Ghiadoni, L et al. “Mental stress induces transient endothelial dysfunction in humans.” Circulation vol. 102,20 (2000): 2473-8. doi:10.1161/01.cir.102.20.2473
  • Sloan, R.p., et al. “Effect of Mental Stress throughout the Day on Cardiac Autonomic Control.” Biological Psychology, vol. 37, no. 2, 1994, pp. 89–99., doi:10.1016/0301-0511(94)90024-8.
  • Cohen, S., et al. “Chronic Stress, Glucocorticoid Receptor Resistance, Inflammation, and Disease Risk.” Proceedings of the National Academy of Sciences, vol. 109, no. 16, 2012, pp. 5995–5999., doi:10.1073/pnas.1118355109.

Chapter 19

  • Savitz, Eric. “The Untapped Power Of Smiling.” Forbes, Forbes Magazine, 10 Aug. 2011, available at: www.forbes.com/sites/ericsavitz/2011/03/22/the-untapped-power-of-smiling/#65b802d37a67.
  • Harvard Health Publishing. “The Happiness-Health Connection.” Harvard Health, available at: www.health.harvard.edu/healthbeat/the-happiness-health-connection.
  • Abel, Ernest L., and Michael L. Kruger. “Smile Intensity in Photographs Predicts Longevity.” Psychological Science, vol. 21, no. 4, 2010, pp. 542–544., doi:10.1177/0956797610363775.
  • Moskowitz, Clara. “Smiles Predict Marriage Success.” LiveScience, Purch, 14 Apr. 2009, available at: www.livescience.com/3503-smiles-predict-marriage-success.html.
  • “Health | Scanner Shows Unborn Babies Smile.” BBC News, BBC, 13 Sept. 2003, available at: news.bbc.co.uk/2/hi/health/3105580.stm.